ingestible · for dry skin & eczema (atopic dermatitis)
Evening Primrose Oil (Oral)
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
If trialing: 500 mg capsules 2-4 times daily with food, for a minimum 12-week trial period. Some practitioners suggest 2-4 g/day total. Results, if any, take weeks to months to appear.
How it works
Evening primrose oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid. The theory is that people with eczema have impaired delta-6-desaturase enzyme activity, leading to GLA deficiency and defective skin barrier lipids. However, clinical trials have not confirmed this mechanism translates to symptom improvement.
Where to buy
Jarrow Formulas Evening Primrose Oil 1300 mg (Amazon, iHerb); Nature Made Evening Primrose Oil (Walgreens, CVS); Solgar Evening Primrose Oil 1300 mg (Whole Foods, Amazon).
Typical cost: $12-$25 for 60-90 capsules
Safety notes
Evidence does not support clinical use for eczema based on current Cochrane-level evidence. May interact with blood-thinning medications (warfarin, aspirin). Avoid during pregnancy. Can cause mild GI upset. Do not use as a substitute for proven treatments.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
Bamford et al., Oral evening primrose oil and borage oil for eczema, Cochrane Database Syst Rev, 2013This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.