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ingestible · for hormonal acne

DIM (Diindolylmethane)

Reviewed by the Nimbera editorial team · Last updated May 2026

Keene S. et al. (2024) "Exploring the impact of 3,3'-diindolylmethane on the urinary estrogen profile of premenopausal women." BMC Complementary Medicine and Therapies, 24:406 (PMID 39578798). Retrospective cohort of 909 DIM users vs 18,385 non-users; women taking DIM had significantly higher 2-hydroxy estrogen metabolites and lower 16-hydroxyestrone, consistent with a shift toward less androgenic estrogen metabolism. No acne-specific endpoints were measured.$20-40/month

How to use

Take 100-200 mg DIM daily with a fat-containing meal to improve absorption. Start at the lower end of the dose range for the first 4 weeks. Most commercial supplements pair DIM with BioPerine (black pepper extract) or vitamin E to increase bioavailability. Allow 2-3 menstrual cycles to assess whether breakout pattern changes.

How it works

DIM is formed in the gut from indole-3-carbinol found in cruciferous vegetables. It shifts estrogen metabolism away from the more androgenic 16-alpha-hydroxyestrone toward the less active 2-hydroxyestrone metabolite, which may reduce androgenic stimulation of sebaceous glands.

Where to buy

Health food stores and online. Look for formulations labeled "absorption-enhanced" or combined with BioPerine. Brands include Thorne, Jarrow, and Life Extension. Plain DIM without an absorption enhancer has poor bioavailability.

Typical cost: $20-40/month

Safety notes

DIM alters estrogen metabolism and should not be used during pregnancy or breastfeeding. May reduce efficacy of hormone-sensitive medications including hormonal contraceptives - discuss with your prescriber before starting. Common side effects include headache, darkened urine (harmless), and temporary GI upset. High doses (above 300 mg/day) have been associated with nausea. Individuals with estrogen receptor-positive cancers should consult an oncologist before use. Evidence for acne specifically is indirect - no acne-specific RCTs have been published as of 2025.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Keene et al. 2024, BMC Complement Med Ther

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.