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ingestible · for lower back pain

Devil's Claw (Harpagophytum procumbens)

Reviewed by the Nimbera editorial team · Last updated May 2026

Chrubasik et al. (n=197) RCT: Harpagophytum extract WS 1531 at 1200 mg/day (100 mg harpagoside) produced 10 pain-free patients vs 3 in placebo (p=0.027) over 4 weeks. PMID 10101629.$15-$35 per month

How to use

Take a standardised extract providing 50-100 mg harpagoside daily, in capsule or tablet form, with water. Benefits typically emerge after 2-4 weeks of consistent use.

How it works

Harpagoside, the primary iridoid glycoside, inhibits COX-2 and pro-inflammatory cytokines (TNF-alpha, IL-1beta), reducing the inflammatory cascade that drives musculoskeletal pain.

Where to buy

Health food stores, pharmacies, and online retailers. Look for standardised extracts (WS 1531 or similar) guaranteeing harpagoside content.

Typical cost: $15-$35 per month

Safety notes

Avoid during pregnancy and if you have gallstones or peptic ulcers. May interact with blood thinners and antidiabetic drugs. Not suitable for children.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Chrubasik et al., Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain, Eur J Anaesthesiol, 1999

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.