ingestible · for urinary health & uti prevention
Cranberry PAC Extract
Reviewed by the Nimbera editorial team · Last updated May 2026
How to use
Take a standardised cranberry extract standardised to at least 36 mg proanthocyanidins (PAC) per dose, once daily. Look for products specifying PAC content from A-type proanthocyanidins - not just milligrams of cranberry powder. Take consistently for 12-24 weeks for best results. Cranberry juice requires very high volumes (300-500 mL/day unsweetened) to match supplement PAC levels.
How it works
Cranberry's A-type proanthocyanidins (PACs) prevent type P-fimbriated E. coli - the bacteria responsible for most UTIs - from adhering to the uroepithelial cells lining the bladder. Without adhesion, bacteria cannot colonise and are flushed out during urination. This anti-adhesion effect requires a threshold PAC dose of at least 36 mg/day to produce measurable anti-adhesive activity in urine.
Where to buy
Ellura (36 mg PAC per capsule, clinician-recommended), Theracranin, NOW Foods Cranberry Concentrate, Utiva Cranberry PACs, Jarrow Formulas Cran Clearance. Available at CVS, Walgreens, Amazon, and iHerb. Confirm the label states PAC content (not just total cranberry mg).
Typical cost: $15-$40/month for a quality standardised extract
Safety notes
May interact with warfarin (anticoagulant) - some studies show modest INR elevation; monitor closely if on warfarin. Not recommended as a sole treatment for active UTI. High-sugar cranberry juice products are not equivalent to PAC extracts and may worsen blood sugar control in diabetics. Safety in pregnancy is considered low risk but consult your OB before use. Very high intakes may increase risk of kidney stones in people prone to oxalate stones.
Drug & supplement interactions
- Always tell your doctor or pharmacist about any supplements you take.
- Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
- Herbal remedies can affect how the body absorbs or metabolises drugs.
- Check drugs.com interactions checker before starting.
Clinical source
Xiong 2024 - Frontiers in Nutrition (PMID 39668896)This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.