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ingestible · for hay fever (seasonal allergies)

Butterbur (Petasites hybridus)

Reviewed by the Nimbera editorial team · Last updated May 2026

A randomized controlled trial published in BMJ (2002) found butterbur extract Ze 339 was as effective as cetirizine (Zyrtec) for treating seasonal allergic rhinitis without causing drowsiness.$20-$45 per month

How to use

Take standardized butterbur extract (Ze 339 or similar) at 8 mg petasin per tablet, one tablet four times daily during allergy season. Always use PA-free (pyrrolizidine alkaloid-free) products.

How it works

Butterbur contains petasins that inhibit leukotriene and histamine synthesis, reducing nasal inflammation and allergy symptoms through a different pathway than antihistamines.

Where to buy

Health food stores, iHerb, Amazon - look for certified PA-free products from brands like Petadolex or NOW Foods

Typical cost: $20-$45 per month

Safety notes

Only use PA-free certified extracts - raw butterbur contains pyrrolizidine alkaloids that are toxic to the liver. Not for use during pregnancy or breastfeeding. Avoid if allergic to ragweed family plants.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Schapowal et al. 2002

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.