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ingestible · for cognitive decline & brain aging

Bacopa Monnieri (Brahmi)

Reviewed by the Nimbera editorial team · Last updated May 2026

Kongkeaw 2014 J Ethnopharmacol (PMID 24252493) - meta-analysis of 9 RCTs (437 subjects) on standardized Bacopa monnieri extract found significantly shortened Trail Making Test B time (-17.9 ms; 95% CI -24.6 to -11.2; p < 0.001) and decreased choice reaction time (-10.6 ms; 95% CI -12.1 to -9.2; p < 0.001), indicating meaningful improvement in attention speed. Effects were observed with chronic use of 12+ weeks.$15-$30/month

How to use

Take 300-450 mg/day of a standardized extract containing 55% bacosides (the active constituents) with a fat-containing meal to improve absorption. Effects are gradual - most RCTs used 12-week minimum durations. Do not expect immediate results.

How it works

Bacosides A and B (the active steroidal saponins) enhance synaptic transmission by increasing serotonin and acetylcholine activity. Bacopa also upregulates antioxidant enzymes (superoxide dismutase, catalase), reduces neuroinflammation via inhibition of TNF-alpha and IL-6, and may support dendritic branching in the hippocampus.

Where to buy

Himalaya Organic Bacopa, NOW Foods Bacopa Extract, Life Extension Bacopa (Synapsa brand standardized extract), Jarrow Formulas Bacopa - widely available at health food stores and online. The Synapsa trademarked extract has the most clinical trial data.

Typical cost: $15-$30/month

Safety notes

Most common side effects are gastrointestinal - nausea, bloating, and loose stools, especially on an empty stomach. Always take with food. May slow heart rate slightly; use caution in bradycardia. Possible interaction with anticholinergic medications (works by opposing mechanism). Avoid during pregnancy. Not proven to treat Alzheimer's disease or MCI - evidence is in healthy and mildly aging adults.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Kongkeaw 2014 - J Ethnopharmacol (PMID 24252493)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.