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ingestible · for alcohol hangover

B-Vitamin Replenishment (B-Complex + Hydration)

Reviewed by the Nimbera editorial team · Last updated May 2026

Thomson (PMID 11304071) review documents that alcohol impairs intestinal thiamine (B1) absorption, depletes hepatic B-vitamin stores, and impairs phosphorylation of B vitamins to active forms. No RCT has tested B-complex specifically for hangover; evidence is mechanistic.$8-$20 per month for B-complex tablets

How to use

Take a B-complex tablet providing at least 50 mg thiamine (B1), 50 mg B6, and 400 mcg folate before going to sleep after drinking, alongside 500 ml of water or an electrolyte drink. Repeat in the morning if symptomatic.

How it works

Alcohol is a diuretic that promotes urinary excretion of water-soluble B vitamins, and it directly impairs intestinal thiamine transport and hepatic B-vitamin phosphorylation. Replenishing the B-vitamin pool - especially B1, B6, and B12 - supports mitochondrial energy production and may ease fatigue and cognitive fog.

Where to buy

Pharmacies and supermarkets. Any B-complex providing 50-100 mg of the major B vitamins is suitable. Electrolyte drinks (Liquid IV, Nuun) cover hydration. Pedialyte is an accessible pharmacy option.

Typical cost: $8-$20 per month for B-complex tablets

Safety notes

B-vitamin supplementation does not prevent alcohol-related harm and should not be used to justify drinking. Megadoses of B6 (above 200 mg/day long-term) can cause peripheral neuropathy. Do not exceed stated doses.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Thomson, Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome, Alcohol Alcohol Suppl, 2000

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.