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ingestible · for liver support & detox

Artichoke Leaf Extract

Reviewed by the Nimbera editorial team · Last updated May 2026

Wider et al. 2022 review (J Hepatol, PMID 35949559) - systematic analysis of 5 RCTs found artichoke leaf extract significantly reduced ALT and AST levels in NAFLD patients, with additional beneficial effects on total cholesterol and LDL. Evidence quality rated moderate.$10-$25/month.

How to use

Take 600-1,800 mg/day of artichoke leaf extract (standardised to 5-15% cynarin content) in divided doses with meals. Effects on liver enzymes typically require 8-12 weeks of consistent use. Often combined with milk thistle for synergistic hepatoprotective effect.

How it works

Cynarin and chlorogenic acid (the main active compounds) stimulate bile production and flow (choleretic effect), helping clear waste products from the liver. They also inhibit cholesterol synthesis, reduce triglyceride levels, and have hepatoprotective antioxidant effects. Artichoke extract promotes liver cell regeneration via luteolin and apigenin flavonoids.

Where to buy

Nature's Way Artichoke ($12-$18/90 capsules), Swanson Artichoke Extract ($10-$15/90 capsules), Thorne Artichoke Cell Force ($30-$40, standardised) - available at health food stores and online.

Typical cost: $10-$25/month.

Safety notes

Avoid if allergic to artichoke or other Asteraceae plants. May cause GI gas and bloating (bile flow stimulation increases fat digestion, which some people find uncomfortable initially). Contraindicated in bile duct obstruction (cholagogue effect can worsen obstruction). May increase bile flow which could interact with gallstone management - consult doctor if you have gallstones.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Wider et al. 2022 - J Hepatol (PMID 35949559)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.