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ingestible · for liver support & detox

Artichoke Leaf Extract

Reviewed by the Nimbera editorial team · Last updated May 2026

An RCT published in Phytotherapy Research 2018 (PMID 29520889; n=90 completers) found artichoke leaf extract supplementation significantly reduced total cholesterol, LDL, triglycerides, and liver enzyme levels, with improved ultrasound markers of liver health compared to placebo in subjects with elevated liver enzymes.$10-20/month

How to use

Standard doses in clinical trials range from 600-1,800 mg of artichoke leaf extract daily, typically divided into two or three doses taken with meals. Choose a product standardized to cynarin or total caffeoylquinic acids content. Allow 8-12 weeks to assess effects on liver enzymes and cholesterol.

How it works

Artichoke leaf extract exerts choleretic (bile-stimulating) and antioxidant effects via its active compounds cynarin and luteolin. Increased bile flow supports fat emulsification and elimination of waste compounds, while antioxidant activity reduces hepatocyte oxidative stress.

Where to buy

Health food stores (Whole Foods, Sprouts), online retailers, and some pharmacies. Look for standardized extracts listing cynarin content. Common brands include Jarrow Formulas, Nature's Plus, and Swanson.

Typical cost: $10-20/month

Safety notes

Contraindicated in people with bile duct obstruction - artichoke's choleretic effect can worsen this condition. Use with caution if you have gallstones, as increased bile flow may aggravate symptoms. Avoid if allergic to Asteraceae/Compositae plants (same family as ragweed, chrysanthemums, daisies, marigolds). Safety in pregnancy and breastfeeding has not been established - avoid during these periods. May interact with cholesterol-lowering medications - monitor liver enzymes if combining with statins. Consult your doctor before use if you have any liver or gallbladder condition.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Phytotherapy Research 2018

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.