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ingestible · for anxiety & stress relief

Ashwagandha (KSM-66)

Reviewed by the Nimbera editorial team · Last updated May 2026

A double-blind placebo-controlled RCT (Chandrasekhar et al. 2012, n=64) found full-spectrum ashwagandha root extract reduced stress scale scores by 44%, anxiety and insomnia scores by 69.7%, and serum cortisol by 27.9% compared to placebo after 60 days. Note: ashwagandha is the same adaptogenic herb used for testosterone and male vitality - here studied specifically for stress and anxiety reduction.$15-$35 for a 60-90 capsule bottle (1-3 month supply depending on dose).

How to use

Take 300-600 mg of KSM-66 or Sensoril ashwagandha root extract daily, divided into one or two doses. Can be taken with meals to reduce the chance of stomach upset. Allow 4-8 weeks of consistent use for meaningful effects. Cycle off for 1-2 months after 3 months of continuous use.

How it works

Ashwagandha's withanolides act as adaptogens, modulating the HPA (hypothalamic-pituitary-adrenal) axis to blunt excess cortisol secretion during chronic stress. It also has GABA-mimetic activity and may downregulate stress-responsive proteins in the brain's limbic system.

Where to buy

KSM-66 Ashwagandha by Jarrow Formulas (Amazon, iHerb), Thorne Botanicals Ashwagandha (Thorne.com, Amazon), Gaia Herbs Ashwagandha Root (Whole Foods, Amazon).

Typical cost: $15-$35 for a 60-90 capsule bottle (1-3 month supply depending on dose).

Safety notes

Avoid during pregnancy - may stimulate uterine contractions. Not recommended if you have hyperthyroidism or take thyroid medication without medical supervision, as it may elevate thyroid hormone levels. May interact with immunosuppressants and sedative medications. Rare cases of liver injury have been reported - discontinue if you develop jaundice or abdominal pain. Do not use with autoimmune disease without physician guidance.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Chandrasekhar et al., Ashwagandha for stress & anxiety: RCT, Indian J Psychol Med, 2012

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.