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ingestible · for carpal tunnel syndrome

Alpha-Lipoic Acid + GLA

Reviewed by the Nimbera editorial team · Last updated May 2026

A 2009 randomized trial of 112 patients with moderate carpal tunnel syndrome (Di Geronimo et al.) found 90 days of alpha-lipoic acid 600 mg plus gamma-linolenic acid 360 mg daily significantly improved symptoms, function, and electromyographic measures versus B vitamins.$20-$40 per month

How to use

Take 600 mg alpha-lipoic acid plus 360 mg gamma-linolenic acid (from borage or evening primrose oil) daily for 90 days. Take ALA on an empty stomach 30-60 minutes before a meal for best absorption; GLA can be taken with food. Reassess symptoms at the 3-month mark.

How it works

Alpha-lipoic acid is a mitochondrial antioxidant that reduces oxidative stress in compressed nerve tissue and supports nerve fiber regeneration - it is widely studied in diabetic neuropathy. Gamma-linolenic acid is an omega-6 fatty acid converted to anti-inflammatory prostaglandins, which may reduce swelling of the tenosynovium inside the carpal tunnel.

Where to buy

Health food stores, Amazon, iHerb - ALA from Doctor's Best, NOW Foods, or Nature's Bounty; GLA from NOW Borage Oil or Barlean's Evening Primrose Oil.

Typical cost: $20-$40 per month

Safety notes

ALA can lower blood sugar - diabetics on medication should monitor glucose closely. May cause mild GI upset or rash. GLA may increase bleeding risk with anticoagulants and can interact with seizure medications. Avoid in pregnancy without medical advice. Best used for mild to moderate cases, not as a replacement for surgery in severe cases.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

PubMed - Di Geronimo et al. 2009

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.