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ingestible · for nerve pain & neuropathy

Alpha-Lipoic Acid (ALA)

Reviewed by the Nimbera editorial team · Last updated May 2026

Hsieh 2023 Nutrients (PMID 37630823) - meta-analysis of 10 RCTs (1,242 patients) found oral ALA significantly improved Total Symptom Score and Neuropathy Disability Score in diabetic sensorimotor polyneuropathy, with a dose-related trend at 600-1800 mg/day.$15-$40/month for standard 600 mg dosing

How to use

Take 600 mg once daily with a meal, or as directed by a healthcare provider. Some protocols use 600 mg two to three times daily under medical supervision. Allow 3-5 weeks before evaluating symptom response. The R-ALA (R-enantiomer only) form may be more bioavailable than the racemic mixture, though most clinical trials used racemic ALA.

How it works

ALA is a potent antioxidant that scavenges reactive oxygen species implicated in oxidative stress-driven nerve damage. It regenerates other antioxidants including vitamins C and E and glutathione. In diabetic neuropathy, ALA reduces advanced glycation end-products and improves endoneurial blood flow, addressing core mechanisms of nerve fiber degeneration.

Where to buy

Jarrow Formulas Alpha-Lipoic Acid, Thorne Lipoic Acid, NOW Foods Alpha-Lipoic Acid, and Doctor's Best Alpha-Lipoic Acid are widely available at health food stores, pharmacies, and Amazon. Look for stabilized R-ALA or racemic ALA with third-party testing certification.

Typical cost: $15-$40/month for standard 600 mg dosing

Safety notes

ALA can lower blood glucose - people taking insulin or oral hypoglycemic agents must monitor blood sugar closely, as dose adjustments may be needed. Do not use if you are thiamine (vitamin B1) deficient without correcting the deficiency first, as ALA can worsen thiamine status. May cause nausea, heartburn, or skin rash. Rare reports of insulin autoimmune syndrome. Avoid in pregnancy unless under medical supervision. Do not combine with chemotherapy agents without oncologist approval.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Hsieh 2023 - Nutrients (PMID 37630823)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.