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topical · for wound healing & tissue repair

Aloe Vera (Topical Gel)

Reviewed by the Nimbera editorial team · Last updated May 2026

Burusapat 2018 Plast Reconstr Surg (PMID 29649056) - double-blind RCT found topical aloe vera gel reduced split-thickness skin graft donor site healing time from 13.67 to 11.5 days vs placebo (p < 0.05).$8-$20 for a quality aloe vera gel product

How to use

Apply a thin layer of pure aloe vera gel (ideally from a freshly cut leaf or a product with >95% aloe content and no added alcohol) to clean minor burns, abrasions, or superficial wounds 2-3 times daily. Leave uncovered or cover loosely with gauze. Do not use on deep or surgical wounds without medical guidance.

How it works

Aloe vera gel contains acemannan (a polysaccharide that stimulates macrophage activation and fibroblast proliferation), glycoproteins that reduce inflammation, and anthraquinones with antimicrobial properties. Together these promote re-epithelialisation and reduce inflammatory cytokines in the wound environment.

Where to buy

Pure aloe vera gel is available at pharmacies, health food stores, and online. For wound use choose products with minimal additives. Fresh aloe leaves can be bought at some grocery stores. Avoid products containing alcohol, fragrances, or artificial colors.

Typical cost: $8-$20 for a quality aloe vera gel product

Safety notes

Evidence is mixed - one RCT found aloe vera delayed healing of post-surgical wounds (PMID 2047051), so do not use on sutured or post-operative wounds without speaking to your surgeon. Some people experience contact allergy to aloe; patch test on intact skin first. Do not ingest aloe latex (the yellow sap layer), which acts as a harsh laxative and is not safe internally.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Burusapat 2018 - Plast Reconstr Surg (PMID 29649056)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.