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ingestible · for nerve pain & neuropathy

Acetyl-L-Carnitine (ALC)

Reviewed by the Nimbera editorial team · Last updated May 2026

Li 2015 PLoS One (PMID 25751285) - meta-analysis of 4 RCTs (523 patients) found ALC reduced VAS pain scores by a mean of 1.20 points (95% CI 0.68-1.72) versus placebo, with a stronger effect in diabetic subgroup (MD 1.47).$20-$45/month at typical doses

How to use

Typical studied doses are 500-1000 mg two to three times daily (total 1500-3000 mg/day). Take with or without food. Clinical trials have used durations of 6-12 months. Allow at least 8 weeks to assess effect on nerve pain and regeneration.

How it works

Acetyl-L-carnitine is the acetylated form of L-carnitine, which plays a central role in mitochondrial fatty acid metabolism. In peripheral nerves, ALC supports axonal regeneration, promotes nerve growth factor (NGF) synthesis, and protects mitochondrial function in damaged sensory neurons. It also acts as an acetyl group donor for neurotransmitter synthesis and may have direct analgesic effects through modulation of metabotropic glutamate receptors.

Where to buy

Ensure the product is labeled acetyl-L-carnitine (ALCAR), not plain L-carnitine, which does not cross the blood-brain barrier as effectively. Brands including Jarrow Formulas, Thorne, and NOW are widely available at health food stores and online. Look for USP or NSF certification.

Typical cost: $20-$45/month at typical doses

Safety notes

Generally well tolerated. May cause nausea, restlessness, or a fishy body odor at high doses. People with seizure disorders should use caution as some reports suggest it may lower seizure threshold. May increase the anticoagulant effect of warfarin - monitor INR if combined. Avoid in people with hypothyroidism without medical supervision. Not recommended during pregnancy or breastfeeding.

Drug & supplement interactions

  • Always tell your doctor or pharmacist about any supplements you take.
  • Interactions can occur with prescription medications, blood thinners, and immunosuppressants.
  • Herbal remedies can affect how the body absorbs or metabolises drugs.
  • Check drugs.com interactions checker before starting.

Clinical source

Li 2015 - PLoS One (PMID 25751285)

This information is compiled from primary clinical literature and is for informational purposes only. It is not a substitute for professional medical advice. Read our full disclaimer.